| abstract |
The present invention relates to (S)-2-(2,3-dihydrobenzofuran-3-yl)acetic acid derivatives, their preparation methods, pharmaceutical compositions containing the derivatives and their use as therapeutic agents, especially as GPR40/ Use of FFA1 agonists, specifically providing (S)-2-(2,3-dihydrobenzofuran-3-yl)acetic acid derivatives represented by general formula (I), pharmaceutically acceptable salts or prodrugs thereof . This kind of compound is the agonist of GPR40/FFAR1 receptor, in addition, it also has better prevention and treatment effect on many diseases mediated by GPR40, especially diabetes and the like. Therefore, the compound of the general formula (I) is expected to be developed into a novel drug for treating diabetes and related diseases. The invention also provides a preparation method of the compound. |