http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103145584-B
Outgoing Links
Predicate | Object |
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classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-20 |
filingDate | 2013-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2015-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2015-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-103145584-B |
titleOfInvention | A kind of method of synthesis (3R, 5R)-3,5-dihydroxyl-6-cyano group capronate |
abstract | The invention belongs to technical field of organic chemistry, be specifically related to (3R, 5R)-3,5-synthetic method of dihydroxyl-6-cyano group capronate.Its step comprises: 3-hydroxyl ethyl glutarate and tribromo-acetyl imines benzyl ester (or tribromo-acetyl imines replaces benzyl ester and carries out Benzylationly preparing 3-benzyloxy ethyl glutarate; Again through Ester hydrolysis, Dehydration for 3-benzyloxy chaulmoogric acid acid anhydride; Through catalysis asymmetric alcoholysis preparation (R)-3-benzyloxy-5-alkoxyl group-5-oxopentanoic acid; (R)-2-cyano group-3-oxo-5-benzyloxy pimelic acid diester is prepared through condensation again with cyanoacetate; Through de-esterification preparation (R)-3-benzyloxy-5-oxo-6-cyano group capronate; Through deprotection preparation (R)-3-hydroxyl-5-oxo-6-cyano group capronate; Through asymmetric reduction preparation (3R, 5R)-3,5-dihydroxyl-6-cyano group capronate.The inventive method reaction conditions is gentle, and easy and simple to handle, raw material is cheap and easy to get, and products therefrom has high yield, highly-solid selectively, is applicable to suitability for industrialized production. |
priorityDate | 2013-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 568.