http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103143065-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_53b4d53983adbf56dd0e7d0bf96f8ce5 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-54 |
| filingDate | 2013-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f92347b1c17b22163d135c975412858e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fe2bd0cd7c349312a7bc0672691dd21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d218c3121d9616101bd5a5263e24d877 |
| publicationDate | 2015-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103143065-B |
| titleOfInvention | Tissue engineering scaffold with multi-growth-factor sequential release characteristic |
| abstract | The invention provides a tissue engineering scaffold with multi-growth-factor sequential release characteristic, and belongs to the technical field of dosage form variation and preparation method. In the tissue engineering scaffold, together with the characteristics of microspheres sustained release system and scaffold, PLLA/PEG (poly-lactic acid/polyethylene glycol) sustained release microspheres of growth factors such as BMP-2 (bone morphogenetic protein), VEGF (vascular endothelial growth factor), bFGF (basic fibroblast growth factor) are prepared respectively by the multiple emulsion method, so as to construct the tissue engineering scaffold with multi-growth-factor sequential release characteristic. The method is high in drug activity maintaining degree, low in organic solvent residue and easy to operate. The prepared microspheres are narrow in particle size distribution and have an excellent sustained release effect. The pore size distribution of the composite scaffold is 150-300mu m, the connectivity is excellent, the porosity is 76.84%, the compressive strength is 5.11MPa, and the accumulative release amount of 21 days is 60.6%. The scaffold prepared according to the invention has an application prospect in tissue engineering restoration. |
| priorityDate | 2013-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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