| abstract |
The invention provides a carrier for introducing genes into liver cells in a targeting mode and a preparation method thereof. The carrier is a compound consisting of lipidosome and apolipoprotein, wherein the lipidosome is prepared from bidodecyl dimethylammonium bromide and dioleoyl phosphatidyl ethanolamine and passes through double-layer coated phospholipids follicle modified by distearoyl phosphatidyl ethanolamine-polyethylene glycol-maleimide; and the apolipoprotein is ApoE. According to the constructed targeting gene carrier, the targeting property of the carrier is improved through the affinity concentration of ligand-receptor, the transfection efficiency and the concentration degree in the liver cells are improved, and the carrier has obvious liver cell targeting property and can serve as artificial membranes and excipients of various treatment agents, so that the curative effect of drugs is enhanced. |