| abstract |
The present invention relates to include medical treatment device and the method for the polymer containing bioactivator.The implant design of the present invention is the polymeric device that a kind of medicine loads, such as, and rod, it is designed to control bioactivator, such as clonidine or derivatives thereof, such as clonidine hydrochloride, release within the time period extended, such as 2 months, 3 months, 4 months, even 4 first quarter moons.The preferred biodegradable polymer of described polymer, the most poly-(lactide co Acetic acid, hydroxy-, bimol. cyclic ester) or polylactic acid/polyactide.The challenge using the hydrochloride form of medicine such as clonidine is, the release controlling this highly water soluble drugs makes it be up to 4 first quarter moons.Having been found that the particle size distribution by controlling drug powder, the drug distribution in polymeric matrix evenly, and is controlled.Therefore, the big aggregation causing medicine quickly to discharge can be eliminated. |