http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103130818-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b26e17432236aa949f62b08733832285 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-22 |
| filingDate | 2013-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e70120a8264438e4c447956def4207fa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2f33001312f2fc6ded8f7bb9116609c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b095d703e6c2d384e78de768a06a545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_beb18a6ab82a22b53f04517a9e36955d |
| publicationDate | 2014-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103130818-B |
| titleOfInvention | Bilobalide B compound and preparation method thereof |
| abstract | The invention relates to a bilobalide B compound which is extracted from ginkgo leaf. The bilobalide B compound contains trace amounts of bilobalide K; and the bilobalide B content is higher than 99%, and the bilobalide K content is lower than 0.6%. The invention also relates to a preparation method of the bilobalide B compound, which comprises the following steps: under stirring conditions, adding kieselguhr and ginkgo leaf extract, heating under reflux at 60-73 DEG C for 2-3.5 hours, filtering and concentrating; adding distilled water, removing impurities, separating out the ethyl acetate layer, passing the ethyl acetate layer through an peracidic aluminum oxide column, eluting with water saturated ethyl acetate, and collecting the eluate; concentrating the eluate under reduced pressure until no ethyl acetate smell is emitted, adding a proper amount of ethanol to dissolve the concentrated eluate, adding water until the ethanol content is 60-70%, standing, precipitating coarse crystal, filtering, taking the coarse crystal, and drying; and recrystallizing the coarse crystal sequentially with ethanol and ethyl acetate to obtain the finished product bilobalide B compound. |
| priorityDate | 2013-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.