| abstract |
The invention discloses a phthalylhydrazine (phthalazine ketone) class compound, a salt, hydrate, and solvate or a stereoisomer of the phthalylhydrazine class compound, applications thereof in preparation of medicine for diseases mediated by poly ADP ribose polymerase (PARP), and medicine composition thereof, wherein the compound can be expressed by the following formula (I) and the salt, the hydrate, and the solvate or the stereoisomer of the phthalylhydrazine class compound are acceptable in pharmacy. As an inhibitor of deoxyribonucleic acid (DNA) repairase and poly (ADP-ribose) polymerase, the phthalylhydrazine (phthalazine ketone) class compound can effectively treat the diseases related to PARP such as cancers, neural degeneration diseases and inflammations. |