http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103122319-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5456846495c5fa8a02f5eaae9faae290 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-645 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-02 |
| filingDate | 2012-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_322509f3d4c205e4cdd6afbbea5d6a98 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c374fbfae25934f9ed4d8f187c50168 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6105c603781905a164ac5d56c8998853 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5bce8169a187efc9db5d14df780d01f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ea2092450277d8b634ecae1cda8feca http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c036493227f31c41c25e9ff82587855 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a4f93396f6cba5fe34c41a63db75c6a |
| publicationDate | 2015-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103122319-B |
| titleOfInvention | Yeast with stereoselectivity and lipase activity and method for preparing S-type rivastigmine by biological splitting of yeast |
| abstract | The invention relates to a yeast with stereoselectivity and lipase activity, as well as a method for preparing S-type rivastigmine by biological conversion with utilization of the yeast. The method comprises a step of: selecting a yeast with stereoselectivity and lipase activity from soil and preparing the S-type rivastigmine by biological transformation of the yeast, wherein transformation is performed for 18 hours, and the transformed liquid contains an S-type rivastigmine product of which the ee value is higher than 90%. By utilizing the yeast, enantiomers containing acyl can be split. The invention provides a cultural method and a chiral splitting method of the yeast, and a transformation method in a double-phase system. By utilizing the yeast, chiral splitting can be performed on the compound such as rivastigmine of which the chiral center contains acyl or hydroxyl. Thus, the yeast disclosed by the invention has a very important application value for promoting the development progress of chiral medicaments of China. |
| priorityDate | 2012-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 102.