| abstract |
The present invention relates to heterocyclic compound, it has the effect treating and preventing inflammatory diseases and treatment skin trauma, particularly has the skin barrier of Recover from damaging, alleviates the effect of the inflammation that causes of inflammatory skin disease and pruritus. May be used for alleviating various inflammatory diseases as the compositions of effective ingredient containing the compounds of this invention and wherein proteinase activated receptor 2 (PAR-2) expresses the disease increased. Especially, containing the compounds of this invention as the activity of PAR-2 in the compositions suppression skin of active component, therefore, it can be used as anti-inflammatory composition for inflammatory skin disease such as atopic dermatitis. |