http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103113351-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24d9ecc38bfe407cd9baffd539a4593a |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2013-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0ad256a1b8b7cd901e9bdcd2cea0e34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be37d38b18adae5e5cba1eedd8633d7d |
| publicationDate | 2015-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103113351-B |
| titleOfInvention | Method for preparing optically pure chiral sulfoxide compound |
| abstract | The invention relates to a method for preparing an optically pure chiral sulfoxide compound by asymmetrically oxidizing thioether as a precursor of a sulfoxide compound. The method comprises the following steps of: dissolving a D(L)-tartaric acid monoester monoamide compound and isopropyl titanate into an organic solvent; adding purified water equal to the dosage of a catalyst, heating the purified water to 40-60 DEG C, and reacting at the temperature for 0.5-1.5hours; adding the thioether as the precursor, stirring and dissolving, and then, cooling to 5-15 DEG C; adding organic amine, and stirring for 5-15minutes; dropwise adding a peroxide oxidant, and then reacting at the temperature of 5-15 DEG C for 5-7hours; extracting by using 10-15wt% of ammonia water after the reaction is ended, merging water phases and adjusting the pH value to 7-8; and then, extracting by using ethyl acetate, merging organic phases, and carrying out vacuum concentration to obtain the optically pure chiral sulfoxide compound. After the reaction is ended, a target product with the e.e value of 99.5% can be obtained through simple extraction and concentration, and the yield of the target product is up to 70% or more. |
| priorityDate | 2013-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 96.