http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103113338-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5456846495c5fa8a02f5eaae9faae290 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-30 |
| filingDate | 2013-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_209f7276d6732b2876a12547e427841b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17a2724af2b2dda7928174fdf3bb5cff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e9079a1ffc8b396adb2a7b7cbdd1cf0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51cbe501bc5a0e0a88b68d886958e3f2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_042ba6f78b4df5ab929ec3d2925cf7d8 |
| publicationDate | 2015-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103113338-B |
| titleOfInvention | Asymmetric full-synthesis method of Tanikolide |
| abstract | The invention discloses an asymmetric full-synthesis method of a natural product ()-Tanikolide, belonging to the field of organic synthesis. The ()-Tanikolide has a structure shown in the specification; and chiral tertiary alcohol is created through a synthesis strategy which is completely different from that of the existing document, and the synthesis of ()-Tanikolide is correspondingly selectively finished. The synthesis path takes the optically active amino alcohol as a raw material and comprises the following steps of: performing an oxidation reaction to obtain amino aldehyde with maintained configuration; creating chiral quaternary carbon through three-step continuous reaction including Witting reaction, [2,3]-Meisenheimer rearrangement and catalytic hydrogenation; and finally performing functional group transformation to obtain a target product. The total yield is 35%. The operation is convenient, the reaction conditions are moderate, the method is suitable for large-scale preparation, and the optical rotation of the synthesis product is consistent with the optical rotation and optical rotation direction of the natural product ()-Tanikolide. |
| priorityDate | 2013-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 102.