http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103110966-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c5aff0238904869b9222c816b7b51bcf |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K101-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2013-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f5e328bbb9f7a6feb974c1235f29188 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_605e5b63c526786ac946d1b4d4bc3e45 |
| publicationDate | 2014-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103110966-B |
| titleOfInvention | Fluoride-18 marked dopamine D4 receptor developing agent and preparation method thereof |
| abstract | The invention discloses a fluoride-18 marked dopamine D4 receptor developing agent and a preparation method thereof. The fluoride-18 marked dopamine D4 receptor developing agent is 2-[4-(4-[<18>F] fluorobenzyl) piperazine-1-yl methyl] pyrazolo [1, 5-alpha] pyridine, and the structural formula of the developing agent is shown in a formula (I). The preparation method comprises three steps of: step one, reacting pyrazolo [1, 5-alpha] pyridine-2-formaldehyde with N-formoxyl piperazine to generate 2-[4-piperazine formaldehyde-1-yl methyl) pyrazolo [1, 5-alpha] pyridine; step two, hydrolyzing 2-[4-piperazine formaldehyde-1-base methyl) pyrazolo [1, 5-alpha] pyridine under a strong acidic condition to generate 2-[4-piperazine-1-yl methyl) pyrazolo [1, 5-alpha] pyridine; and step three, reacting 2-[4-piperazine-1-yl methyl) pyrazolo [1, 5-alpha] pyridine with 4-[<18>F] fluorobenzaldehyde to generate a target molecule. 2-[4-(4-[<18>F] fluorobenzyl) piperazine-1-yl methyl] pyrazolo [1, 5-alpha] pyridine prepared by the method can be used for dopamine D4 receptor development and is a specific dopamine D4 receptor developing agent. |
| priorityDate | 2013-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 87.