http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103110621-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aa290cfbc4cd90be40bdc3dfa6829f54 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-223 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 2013-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3697db9e9df0f7d999c020de0281ce7c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2da2b59acd29fb1991a3e69afbd3ceb5 |
| publicationDate | 2013-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103110621-A |
| titleOfInvention | Applications of tea double-chlorine carboxamide and tea double-bromine carboxamide or like in preparation of products for prevention and treatment of diseases such as cancer |
| abstract | The invention relates to the technical field of medical treatment. The tea double-chlorine carboxamide and tea double-bromine carboxamide are newly synthesized compounds which can inhibit growths and invasions of cancer cells such as lung cancer, breast cancer, liver cancer, stomach cancer, colon cancer, prostate cancer, pancreatic cancer, cervical cancer, lymphoma, leukemia, and melanoma, and can obviously inhibit the tumor growth and metastasis in the body, and the inhibition effect of the compound is better than that of an anticancer medicament; the mechanism of action involves a receptor which is closely related to down-regulation and inhibition of the growth, invasion and metastasis of a tumor, signal transduction and regulation protein and kinase levels and a binding of a nuclear factor and DNA (Deoxyribonucleic Acid), and up-regulation of factors such as tumor suppressor proteins and cell cycle inhibitor proteins simultaneously; double tea chlorine carboxamide and double tea chlorine carboxamide can directly inhibit activities of histone deacetylase and histone methyltransferase EZH2(Enhancer Of Zeste Homolog 2) and the binding of the inflammatory factor NF-kB and DNA, and the activities of tea double-chlorine carboxamide and tea double-bromine carboxamide are better than that of the clinical anti-cancer medicament. The invention provides new applications of tea double-chlorine carboxamide and tea double-bromine carboxamide and intermediate compounds in preventing and treating the diseases such as cancers, inflammation, cardiovascular and immune deficiencies. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104144919-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104144919-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111386261-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020011607-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014048313-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104623676-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104623676-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9518038-B2 |
| priorityDate | 2013-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 217.