http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103102267-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-30 |
| filingDate | 2011-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103102267-B |
| titleOfInvention | A kind of preparation method of pharmaceutical excipient grade glyceryl behenate |
| abstract | The invention relates to the field of drug synthesis, in particular to a preparation method of pharmaceutical excipient grade glyceryl behenate. The method according to the present invention comprises the steps: (1) adding behenic acid and glycerin in the reactor and stirring evenly; (2) directly raising the temperature for dehydration esterification reaction; (3) adding activated carbon for decolorization and filtering while hot; (4) adding purification Cooling with water for crystallization, centrifugation, drying, and crushing to obtain pharmaceutical excipient grade glyceryl behenate. The present invention uses behenic acid and glycerin to directly dehydrate and esterify glyceryl behenate to prepare glyceryl behenate, without adding catalysts such as concentrated sulfuric acid, p-toluenesulfonic acid, solid acid, etc.; and without adding other reaction solvents; In addition, product refining is more convenient. The process produces less "three wastes", is simple to operate, and has a yield of more than 89%, which is suitable for industrial production, and the quality can meet the requirements of pharmaceutical excipients. |
| priorityDate | 2011-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.