http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103096932-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6455 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1077 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-435 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 |
| filingDate | 2011-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103096932-B |
| titleOfInvention | Cell-penetrating peptides and application thereof |
| abstract | The present invention relates to can in dissolve the peptide molecule of cell, wherein this peptide molecule: (a) has at least 10, the preferably at least length of 15 amino acid residues；B () comprises at least 25% in its primary amino acid sequences, preferably at least 30% positively charged amino acid residue；(c) to have at least the 80% of the internalization effect of the tat peptide of aminoacid sequence GRKKRRQRRRPPQ, in the effect of preferably at least 90%, cell is dissolved.The invention still further relates to the nucleic acid molecules encoding this peptide of correspondence, and comprise the compositions of at least one this peptide, this peptide is attached to one or more nucleic acid molecules, one or more peptide or protein, one or more little molecule, with any one in one or more nano-particle, wherein by reaching this attachment selected from the connection of covalent bond and non-covalent bond.Moreover, it relates to the method detecting the internalization behavior of this peptide or this compositions, comprising: one or more cells are used this peptide or compositions by (a)；(b) internalization of this peptide or compositions is detected.Finally, the present invention relates to this peptide or this compositions and converting or transfecting the purposes in one or more cell, and the purposes in the disease of cancer, immunological diseases, cardiovascular disease, sacred disease, infection and inflammatory diseases in prevention and/or treatment. |
| priorityDate | 2010-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 452.