abstract |
A class of vanillic acid 1,3,4-oxadiazole derivatives with the following general formula: where R1 is: where R1 is: Vanillic acid acylhydrazone derivatives of the present invention are effective against Bacillus subtilis (B.subtilis), Staphylococcus aureus (S.aureus), Escherichia coli (E.coli), Pseudomonas aeruginosa (P.aeruginosa), feces Enterococci (S.faecalis) have different inhibitory effects, so the vanillic acid 1,3,4-oxadiazole compounds of the present invention can be used in the preparation of antibacterial drugs. The invention discloses its preparation method. |