| abstract |
The invention provides a preparation method of a lysozyme curcumin nanoparticle. The method includes a curcumin nanoparticle preparation step, and also includes the following steps of: mixing the curcumin nanoparticles with lysozyme in a solvent, adding a polypeptide coupling agent and stirring them, with the curcumin nanoparticles and the lysozyme being in a mass ratio of 1:4-5; and then dialyzing the stirred solution, carrying out concentration and vacuum drying, thus obtaining the lysozyme curcumin nanoparticle. The method provided in the invention prepares curcumin particles containing kidney targeted lysozyme and having a small size effect, so that renal fibrosis can be treated effectively. |