| abstract |
The invention provides a kind of polycaprolactone-poly phosphate segmented copolymer, the liquid composition be made up of this segmented copolymer, the preparation method of a kind of nucleic acid preparation and above-mentioned multipolymer and liquid composition and their application in nucleic acid drug drug delivery system.The segmented copolymer that the present invention obtains has good biocompatibility, low cytotoxicity and degradability.Micella provided by the invention; self-assembly forms nano particle in aqueous; there is satisfactory stability, biocompatibility, low cytotoxicity and degradability; and preparation method is simple; repeatable high; the small nucleic acids such as siRNA can be protected to avoid degraded as carrier, again can the scale effect of combining nano particle itself, for the treatment of various disease.In addition, the specific recognition to different carcinoma cell can also be realized by bonding target group. |