http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103073613-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_33bc06c3426a944a9ca92d281bcb7784 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d40285e27f4ed83b8728b0d477404958 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J31-00 |
| filingDate | 2012-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5569cfb6a8e2cbecdffdf5fc4e86a342 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94130228764cba4c7f7208f70371e3d3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f12469b149ff4525d741d2e37d9bdf44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05a83bbcc2df8df5cdda118c25efea1a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36ce9c83ee6c98f91cec84a7f91f55d6 |
| publicationDate | 2013-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103073613-A |
| titleOfInvention | A kind of synthetic method of fluticasone derivative |
| abstract | The invention discloses a method for synthesizing fluticasone derivatives represented by formula (I). The compound represented by formula (II) is subjected to decarboxylation and fluorination under the action of a monovalent metal silver salt catalyst and a selective fluorination reagent. The substitution reaction produces fluticasone derivatives as shown in formula (I). The traditional preparation of propionic acid (furoic acid) fluticasone (I) is generally obtained from (III) by condensation of bromofluoromethane, but bromofluoromethane has high cost, high toxicity and serious environmental hazards. The reagents used in the invention are relatively cheap and easy to obtain, with little environmental pollution, mild reaction conditions, good selectivity and high reaction yield. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111662353-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111751455-A |
| priorityDate | 2012-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.