http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103073439-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b26e17432236aa949f62b08733832285 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-08 |
| filingDate | 2013-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1818cba9689657499e79582717920f5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85bd9842407f8efc65f46c091955e6e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_413e724675443db678884e1d16234836 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9dd81fcc3773199851d7a94872b8176f |
| publicationDate | 2013-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103073439-B |
| titleOfInvention | Synthesis method of ambroxol hydrochloride compound |
| abstract | The invention relates to a synthesis method of an ambroxol hydrochloride compound, comprising the following steps of: 1) taking a compound of a formula (I) as a starting raw material; taking DMAP (Dimethylaminopyridine) and 4-dimethylamino cyclohexanol as catalysts to react with p-amino cyclohexanol under the condition of the presence of absolute methanol and anhydrous potassium carbonate to obtain an intermediate; and 2) under the condition of the presence of a solvent ethanol, water and glacial acetic acid, taking the intermediate and concentrated hydrochloric acid to react to generate ambroxol hydrochloride. According to the synthesis method disclosed by the invention, diacetylamido is used for carrying out complete protection on active nitrogen atoms of the starting raw material to avoid a benzene ring 2-substituents amino secondary reaction; the difficulties of the prior art that more condensation secondary reactions, low yield, high catalyst cost, harsh process conditions and the like are overcome to form a novel process with a short reaction line, moderate conditions and small pollution; the yield is higher than 67%; impurity types and contents are obviously reduced; and only one of five known impurities exists and the product purity is more than 99.9%. The formula (I) is shown as the specification. |
| priorityDate | 2013-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.