| abstract |
The invention discloses a preparation method of α-hydroxymethyl-α-aryl-α-amino acid derivatives, which uses aryl diazo, aniline and aliphatic aldehyde as raw materials, rhodium acetate as catalyst, and organic solvent as Solvent, after a one-step reaction, the product α-hydroxymethyl-α-aryl-α-amino acid derivative is obtained. The preparation method of the invention has the advantages of efficient atom economy, high selectivity, high yield, etc., and the operation is simple, safe and reliable. |