http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103070868-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-12 |
| filingDate | 2013-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103070868-B |
| titleOfInvention | A kind of IDO inhibitor containing NH-1,2,3-triazole and preparation method thereof |
| abstract | The invention belongs to technical field of medicine synthesis, be specifically related to a kind of IDO inhibitor containing NH-1,2,3-triazole and preparation method thereof.The present invention with the antitumor drug Erlotinib (Erolotinib) containing acetenyl for raw material, under cuprous catalysis, after reacting with TMSA or p-toluene sulfonyt azide, introduce a NH-1,2,3-triazole group, synthesizing new is containing NH-1, the IDO inhibitor of 2,3-triazole.Novel 1 of the present invention's synthesis, 2,3-triazole can be used as efficient IDO inhibitor, be expected to be applied to the disease that treatment has the pathological characteristics of the tryptophan metabolic pathway of IDO mediation, such disease at least comprises neoplastic disease, cancer, Alzheimer, autoimmune disease, cataract, mood disorders, depression, anxiety neurosis.The inventive method has simple to operate, mild condition, with low cost, yield advantages of higher, has broad prospect of application, is easy to suitability for industrialized production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106928069-A |
| priorityDate | 2013-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 283.