http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103060248-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-465 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 |
| filingDate | 2011-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103060248-B |
| titleOfInvention | Method for constructing gene engineering FK506 high-producing strain and streptomyces tsukubaensis high-producing strain |
| abstract | The invention discloses a method for constructing a gene engineering FK506 (tacrolimus) high-producing strain and a streptomyces tsukubaensis high-producing strain. A receptor strain integrated in genome with a multiplication expression box expressing genes associated with biosynthesis of FK506 has the ability of stably producing FK506 in high yield. Specifically, in a site-specific integration mechanism mediated gene recombination way, endogenous genes associated with precursor biosynthesis in an FK506 gene cluster are multiplied to a streptomyces chromosome to directionally reconstruct the streptomyces producing FK506, so as to obtain an FK506 high-producing strain. The invention also discloses the application of the FK506 high-producing strain. |
| priorityDate | 2011-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 120.