http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103058926-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c622a3a24eaaeba41f660fcd5358bcc7 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-42 |
| filingDate | 2012-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ed6ed1014c02aa14430940507b591d6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_704519111d2173c3d2d5e9b28e041012 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8664723a9a42efcc0bb5aa041cc3f85b |
| publicationDate | 2014-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103058926-B |
| titleOfInvention | Preparation method of 7-chlorine-4-(piperazineyl-1-yl) quinoline |
| abstract | The invention belongs to synthesis field, especially to a preparation method of 7-chlorine-4-(piperazineyl-1-yl) quinoline. The preparation method includes dissolving the piperazine into water and heating, returning and stirring the piperazine and 4,7--dichloroquinoline according to a feeding molar ratio of 1:(3-6)to react for four hours in acidic condition and filtering the reaction liquid after the reaction is finished, adding caustic soda flakes into filtrate, adjusting the filtrate to basicity, cooling, crystallizing and obtaining 7-chlorine-4-(piperazineyl-1-yl) quinoline. The preparation method with simple is simple in preparation process, high in product quality and high in yield ratio. Moreover, the method avoids to use poisonous organic reagents, which is environmental and suitable for industrial production. |
| priorityDate | 2012-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.