http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103058879-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-24 |
| filingDate | 2012-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103058879-B |
| titleOfInvention | The preparation method of Agomelatine |
| abstract | The present invention relates to technical field of medicine synthesis, be specifically related to a kind of preparation method of Agomelatine.To in magnetic force reactor, add cholamine solution 38.5 ~ 39.5L, formula (I) compound 5290 ~ 5305g and Raney/Ni catalyzer 519 ~ 521g, logical ammonia displacement, closed reactor, logical pressurized with hydrogen to 4.5 ~ 5MPa, check reactor resistance to air loss, temperature rises to 70 ~ 90 DEG C, stirring reaction 4 ~ 5h; After completion of the reaction, be cooled to 30 ~ 45 DEG C, in reactor, hydrogen is slowly emptying, and reaction solution extrudes through liquid outlet opening, load transfer container, filtration catalizer, filtrate decompression is distilled, concentrated end, be cooled to 25 ~ 35 DEG C, obtain oily matter, be i.e. formula (II) compound.The preparation method of Agomelatine of the present invention, preparation technology is simple and direct, is suitable for suitability for industrialized production, and yield is higher, effective Reaction time shorten.Meanwhile, process for refining is comparatively simple and direct, and product purity is higher. |
| priorityDate | 2012-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.