http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103044539-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-107 |
| filingDate | 2010-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103044539-B |
| titleOfInvention | Reorganizational hemopoietin and preparation method thereof |
| abstract | The invention relates to reorganizational hemopoietin with chemical modification and a preparation method thereof. The method adopts genetic engineering technology to reorganize hemopoietin, and introduces 4-acetophenone alanyl residue with chemical active ketone group into the hemopoietin; polyethylene glycol specifically reacts with the 4-acetophenone alanyl residue when polyethylene glycol carries out covalent modification on the reorganizational hemopoietin, the reaction is complete, reaction with other amino acid residues is avoided, and the required reaction condition is mild, therefore, the method solves the problems of bad selectivity and adverse reaction condition in the prior art. The pharmacokinetic study result and the haematocrit determination result of the reorganizational hemopoietin pegylation of pegylation are both superior to the natural erythropoietin. |
| priorityDate | 2010-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 889.