http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103044402-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cacfb14a5e5131dd590be214c723caa8 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2012-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87e20e7f2958bad52fa53b6be8497056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0a777016b18c71ec0e65ef6ad855fcf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dde0b388cba7d0a96f6d9dac6009e01f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c28b5399aacc86b62b88a5e1a2fb7206 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebfae5f0fc4734570145873a8cc9e040 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_efbabaac872e8d0805573bdab31b4e17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6417859ad66eb5db4ebeaad03f90bc9d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1f682796eb1071e1206dc52e6909118 |
| publicationDate | 2015-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103044402-B |
| titleOfInvention | Method for synthesizing esomeprazole sodium |
| abstract | The invention discloses a method for synthesizing esomeprazole sodium. The method comprises the steps as follows: preparing 5-methoxy-2-(4-methoxy-3,5-dimethyl-2-pyridyl) methylthio-1H-benzimidazole, namely prochirality thioether; preparing crude esomeprazole sodium; refining the crude esomeprazole sodium; adding the prepared prochirality thioether and dried methylbenzene into D-(-) diethyl tartrate and water by stirring, adding titanium isopropylate, and stirring; and adding diisopropylamine at constant temperature, stirring, dropwise adding cumyl hydroperoxide with the mass concentration of 80%, ending the reaction, extracting, salifying, concentrating, washing and carrying out vacuum drying to obtain a crude product, and refining the crude product to obtain the esomeprazole sodium. The method is low in cost, toxicity and pollution, easy to operate, short in reaction time, high in product purity and easy for industrial production. |
| priorityDate | 2012-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 77.