http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103044373-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3be7b370eaad434728ca8c2191d45fe7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-77 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-94 |
| filingDate | 2012-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a7e405c502c1c8567752afc98e2f50e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fdc73cc9489e91dfbb5dd5afe030e700 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9bf507bea73693961c2d96d18c03a96 |
| publicationDate | 2014-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103044373-B |
| titleOfInvention | Process for preparing optically active antrocin |
| abstract | The present invention relates to a process of preparation of optically active antrocin. At first, to introduce the correct configuration of trans-decalone, alkyl aluminum/TMSCN was used to react with decalenone. The resulting racemic nitrile-decalone was resolved with chiral diol by ketalization to produce two chromatography separable diasteromers. After a simple column chromatography, optically pure compounds were obtained. Formylation was a critical step for the lactone formation. The rest of the synthesis is straight forward through oxidation and olefination. Accordingly, the total synthesis was completed in 10 steps with 7% overall yield from commercially available 6-methoxy-2-tetralone. |
| priorityDate | 2011-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 98.