http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103044338-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-04 |
| filingDate | 2012-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103044338-B |
| titleOfInvention | MiR-21 micromolecular inhibitor and application |
| abstract | The present invention relates to a kind of miR 21 micromolecular inhibitor and application.Medicine of the present invention is to express by specificity suppression miR 21, and then promotes compound 2,4 diaminourea generation 1,3 diaza own ring 5 nitriles of kinds of tumor cells apoptosis.2,4 diaminourea generation 1,3 diaza own ring 5 nitriles meet binding ability Ki=1.49nM, deltaG=12.04kcal/mol with miR 21.Its preparation includes: by compound 2,4 diaminourea generations 1,3 diaza own ring 5 nitriles are dissolved in deionized water and are made into mother solution, after add tumor cell (glioma, gastric cancer and breast carcinoma) cultivating system by a certain percentage, can express by specific suppression miR 21, and have substantially no effect on other miRNA and express.Cell cycle occurs that the G0/G1 phase blocks simultaneously, and percentage of cerebral apoptosis example substantially increases, and tumor realizes more effectively suppression. |
| priorityDate | 2012-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 63.