http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103040757-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-00 |
| filingDate | 2012-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103040757-B |
| titleOfInvention | Core-shell drug nano-particles, as well as preparation method and application thereof |
| abstract | The invention discloses a core-shell drug nano-particle which comprises a hydrophobic inner core and a shell, wherein the inner core comprises a hydrophobic polymer and a first drug adsorbed on the hydrophobic polymer, the shell comprises a single layer of lipid molecules, an amphiphilic compound and a second drug, the hydrophobic inner core is wrapped by the single lipid layer formed by the single layer of lipid molecules, the single lipid layer has a hydrophobic part facing the hydrophobic inner core and a hydrophilic part facing the outside of the drug nano-particle, the amphiphilic compound has a lipid terminal and a hydrophilic terminal covalently cross-linked with the lipid terminal, the lipid terminal of the amphiphilic compound is inserted into the single lipid layer, the second drug is adsorbed to the lipid terminal of the amphiphilic compound and the single lipid layer. The drug nano-particle disclosed by the invention can achieve the effect of multi-stage release of the first and the second drugs and is prepared according to a two-step method. |
| priorityDate | 2012-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.