http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103040725-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_253331f14c912c8035cfbb023087f6d0 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-585 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 |
| filingDate | 2012-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c120f3d613e78561e291a6cb3acb6ae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75966fd24d6e7bebdad1df039174be07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d49482f61693d6be529ffd15992bfb1 |
| publicationDate | 2015-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103040725-B |
| titleOfInvention | Method for modifying dissolution of drospirenone by using grinding and drospirenone solid dispersion |
| abstract | The invention belongs to the scientific field of pharmaceutic preparations, and in particular relates to a method for modifying dissolution of drospirenone by using grinding and drospirenone solid dispersion. The method comprises the following steps: (1) the drospirenone and hydrophilic non-polymer accessories or water soluble accessories are evenly mixed by the mass ratio of 1:(1-1):30; and (2) the evenly mixed materials are fully grinded or milled, and are screened. The method has the advantages of simple operation, low cost, simplicity, practicability and convenience in promotion; the preparation produced by drospirenone dispersion which is prepared by the method is quickly dissolved out; 80 percent of drospirenone can be furthest dissolved out in 10 minutes; and 98 percent of drospirenone can be furthest dissolved out in 20 minutes; the drospirenone is quickly dissolved out; the biological utilization rate is high; no organic solvent is remained; the stability is high; and the method is suitable for preparing solid preparation. |
| priorityDate | 2012-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.