| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69ece09bafee7e0c49d1f7951a3faa2c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-912
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4701 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57496
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5308
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 |
| filingDate |
2011-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e297dbb9e1cb7ea094abdf374834d2f6 |
| publicationDate |
2013-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-103038643-A |
| titleOfInvention |
FOXO3A as a predictive biomarker of PI3K/AKT kinase pathway inhibitor potency |
| abstract |
The present invention provides a method for predicting the sensitivity of tumor cell growth to inhibition produced by PI3K/AKT kinase pathway inhibitors, comprising: determining the localization and distribution of FOXO3a in tumor cells, wherein the cytoplasmic localization and distribution of FOXO3a is related to the inhibition by PI3K/AKT kinase Sensitivity to inhibition by inhibitors and the nuclear localization profile of FOXO3a correlates with resistance to inhibition by PI3K/AKT kinase inhibitors. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106715719-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107076727-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105492630-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11015229-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107076727-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106715719-A |
| priorityDate |
2010-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |