http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103030661-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-38 |
| filingDate | 2012-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103030661-B |
| titleOfInvention | The preparation method of ibronate sodium |
| abstract | The preparation method that the invention provides a kind of ibronate sodium comprises the following steps: 3-methylamino-propionitrile is carried out in the DMF solution of Anhydrous potassium carbonate pentyl with positive bromo pentane silane and be obtained by reacting 3-(N-methyl--V-pentyl) aminopropionitrile; 3-(N-methyl--V-pentyl) aminopropionitrile and phase-transfer catalyst are hydrolyzed in the basic conditions and are obtained by reacting 3-(N-methyl--V-pentyl) alanine; 3-(N-methyl--V-pentyl) alanine and phosphorous acid, sulfur oxychloride are carried out two banks under toluene existent condition, hydrolysis reaction obtains Ibandronic acid; Ibandronic acid is carried out in the basic conditions neutralization reaction and obtain ibronate sodium.Solve the yield of ibronate sodium in prior art low, purity is low, and step is many, the technical problem that production cost is high. |
| priorityDate | 2012-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 72.