http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103030641-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_502b4df741f3b55e3a0a591b504b60bb |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2012-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84ce750b2d140f8d2d14a7af5b00238d |
| publicationDate | 2013-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103030641-A |
| titleOfInvention | A kind of preparation method of pemetrexed disodium key intermediate |
| abstract | The present invention relates to a kind of preparation method of pemetrexed disodium key intermediate, more specifically relate to a kind of method of high yield preparation pemetrexed disodium key intermediate, described method comprises: (a) formula ( I) The compound is used as a raw material, and it is reacted with propylene alcohol to obtain the compound of formula (III); (b) after the compound of formula (III) is condensed with nitromethane, a molecule of water is removed by a dehydrating agent to obtain the compound of formula (IV) ) compound; (c) the compound of formula (IV) generates the compound of formula (V) through Michael addition reaction; (d) the compound of formula (V) is reacted with Nef to obtain the compound of formula (I). The invention has a short reaction route, no harsh reaction conditions, shortens the reaction time, and can remarkably increase the yield of the product. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109721604-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104496899-A |
| priorityDate | 2012-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.