http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103012556-B
Outgoing Links
Predicate | Object |
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classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-20 |
filingDate | 2011-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2014-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2014-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-103012556-B |
titleOfInvention | Method for synthesizing growth hormone secretagogue pentapeptide from solid phase polypeptide |
abstract | The present invention discloses a method for synthesizing a growth hormone secretagogue pentapeptide from a solid phase polypeptide. The method comprises the following steps: adopting a 2-chlorotrityl chloride resin as a starting material, sequentially connecting amino acids having protection groups according a solid phase synthesis method, sequentially removing a Fmoc-protection group during the process, adopting HBTU and HOBT as condensation agents to carry out a peptide binding reaction to obtain a protected pentapeptide resin, synchronously carrying out side chain protection group removing and peptide cutting, collecting the peptide-cut growth hormone secretagogue crude product, carrying out separation purification through a C18 HPLC column, and carrying out freeze drying to prepare the growth hormone secretagogue purified product. The method has the following beneficial effects that: a process is stable, by-products are less, product quality is stable, production cost is low, and the three-waste pollution is low. |
priorityDate | 2011-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 156.