http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103012553-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d59e15bc7181ada202c155b605b34982 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-11 |
| filingDate | 2012-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4268a972f0aa89defdca5efcc2171f24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d6021f3895a08fc3e3736fce7b76f3a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5ed1a8f7d2fa00996281f0a215e7096 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4aac45ebd15c51e406f96987008f79b5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_783faf163d643bb9b81d57615aa74e0f |
| publicationDate | 2014-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103012553-B |
| titleOfInvention | Cortisone-RGD polypeptide conjugate, and preparation method and application thereof |
| abstract | The invention relates to a cortisone-RGD polypeptide conjugate shown in a general formula i, and a preparation method and application thereof. In the general formula i, RGDX is tetrapeptide Arg-Gly-Asp-X, and X is any one of three amino acids of Val, Phe and Ser. Experiments prove that the compound provided by the invention has excellent immunological suppression effect and anti-inflammatory effect and the side effect of osteoporosis is reduced. The compound can be clinically used as an immunological suppressant and anti-inflammatory agent having low side effect of osteoporosis. Meanwhile, the cortisone-RGD polypeptide conjugate can form nano spheres having a stable particle diameter of 200-700 nm through self assembly in a water solution. Thus, the cortisone-RGD polypeptide conjugate can be prepared into an immunological suppression pharmacosome, microemulsion or liposome targeted medicament. |
| priorityDate | 2012-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 82.