http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103012476-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-40 |
| filingDate | 2012-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103012476-B |
| titleOfInvention | A kind of preparation method of bimatoprost intermediate |
| abstract | The invention belongs to pharmaceutical synthesis field, be specifically related to a kind of preparation method of bimatoprost intermediate 2-oxo-4-benzene butyl phosphine dimethyl phthalate, the method adopts dimethyl methyl phosphonate and 3-phenylpropionate to be placed in anhydrous tetrahydro furan/lithium diisopropyl amido,-15 ~ 0 DEG C is kept to react 0.5 ~ 4 hour, thin plate chromatography detects without raw material spot, drip 5mol/L hydrochloric acid to system pH=3.0 ~ 4.0, rise to room temperature, concentrated removing tetrahydrofuran (THF), thin up, ethyl acetate is extracted, by 5mol/L salt acid elution organic phase twice, water washing organic phase twice, saturated aqueous common salt washes twice, anhydrous sodium sulfate drying, concentrating under reduced pressure final vacuum oil pump is evacuated to constant weight and obtains product.The method production technique is simple, and mild condition, is easy to suitability for industrialized production. |
| priorityDate | 2012-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 57.