http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103012436-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_74da19740def035cad82b68c0dca3af7 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-04 |
| filingDate | 2012-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d499ad88c11513127dc7070b6cc0897 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_209141d0c8cec013ff68b17dd6f179c7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b1cf83ef414a3645f8454ca182cb7eb |
| publicationDate | 2015-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103012436-B |
| titleOfInvention | Preparation method of cefotiam hydrochloride |
| abstract | The invention belongs to the technical field of antibiotic drug synthesis, and particularly relates to a preparation method of cefotiam hydrochloride. The preparation method comprises the following steps of: adding formamido thiazole acetic acid to an organic solvent, adding base and dithio-bisbenzothiazole, stirring, then adding a catalyst, and carrying out condensation reaction, thus obtaining an active ester A, wherein the catalyst is triethyl phosphate; dissolving 7-ACMT in an alkali liquor of the organic solvent, adding the active ester A for carrying out N acylation reaction, adding a water solution after reaction is ended, getting a water layer, adding hydrochloric acid for hydrolysis, and dropwise adding a hydrophilic solvent to separate out the cefotiam hydrochloride. The preparation method has the advantages that reaction conditions are mild, strict anhydrous and anaerobic conditions are not needed, the cost is low, the synthesis process is simple, and the purity and the yield are high. |
| priorityDate | 2012-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 70.