http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103012328-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d801ebd8d39e8463e80eb210dfc90de0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b4711b7defc1422cdb7f86d2c95657bf |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D305-14 |
| filingDate | 2011-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61ebc80b3b115073c7e863c0dc04cf4e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_00e3325fafc40c2394027f50a547a0df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7586cebce8252c155b57029d66d10aef http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_860c91d4fc65c67a82b449910027bd11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b29246c75e1a05d5d57276f6d229d00c |
| publicationDate | 2015-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103012328-B |
| titleOfInvention | Method for preparing second-generation taxol anticancer drug Cabazitaxel |
| abstract | The invention belongs to the field of medicament synthesis, and relates to a method for synthesizing a second-generation taxol anticancer drug Cabazitaxel. The method comprises obtaining a key intermediate (II): a 10-deacetyl baccatin III (I) with C-7 and C-10 hydroxy-methylthio-methylene and C-13 hydroxy-oxidization, completing a de-methylthio operation for C-13 carbonyl and C-7 and C-10 methylthio methylene (MTM) of the compound II by a one-pot method to obtain a nucleus (IV) of an XRP6258, connecting the nucleus with various side chains, and then removing side chain protecting groups to obtain the product Cabazitaxel (V). The method has advantages of high efficiency in the preparation process, simple process, high yield, relatively low cost and easy operation, and is suitable for large-scale production and preparation of anti-cancer drugs XRP6258. |
| priorityDate | 2011-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 107.