| abstract |
The invention relates to the field of medicinal chemistry, in particular to a 2-phenylquinazoline derivative. The structural formula of this 2-phenylquinazoline derivative is: In the formula, R 1 is NH(CH 2 ) 3 N(CH 3 ) 2 ; R2 is Cl or H; R 3 is NHCO(CH 2 ) n NR 4 or NHCO(CH 2 ) n NH(CH 2 ) n NR4, n=1, 2, 3, 4 or 5, NR 4 represents two C 1-6 alkyl groups or two C 3-6 cycloalkyl groups connected to the N atom, or NR 4 represents morpholinyl, piperazine base or pyrrolidinyl. The invention also discloses a preparation method of the 2-phenylquinazoline derivative. The 2-phenylquinazoline derivatives involved in the present invention have a strong inhibitory effect on the expression of telomeric DNA, have significant inhibitory effects on various cancer cell lines, and have little toxicity to normal cells, and are useful in the preparation of anticancer drugs. has a broad application space. |