http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103012256-B
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_234543a833f616e568c660b03a3bbdab |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-75 |
filingDate | 2012-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2015-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cff9d14d0fab6c0828b4500a4dd5b662 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b36a136ac26372695a9fb2900fbc3c1d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_435c8857e531ccafe02e1f09b555693f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e69982d8691ffb6a510a84e7d7592906 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80ec5d04a4ad609f5311a49162f20a40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b973b8ffa1c7b8201f7f09e68752baf2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99f76ee240a268244df80fb155a72438 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd1ae33c1ac9debeeeb08fd2a17fe602 |
publicationDate | 2015-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-103012256-B |
titleOfInvention | Method for synthesizing roflumilast |
abstract | The invention provides a method for synthesizing roflumilast, which comprises the following steps: (1) taking 3-cyclopropylmethoxy-4-difluoromethoxybenzoic acid for reaction to obtain 3-cyclopropylmethoxy-4-difluoromethoxybenzoyl chloride or 3-cyclopropylmethoxy-4-difluoromethoxybenzoyl bromide; (2) after the reaction in step (1) is finished, performing amidation on the resultant and 4-amino-3,5-dichloropyridine by using sodium amide as a catalyst; and (3) after the reaction is over, purifying the resultant to obtain refined roflumilast, wherein the mole ratio of sodium amide to 4-amino-3,5-dichloropyridine is greater than or equal to 1. The method uses the specific inorganic base catalyst, namely sodium amide, based on the current roflumilast synthesis process to guarantee the high purity and yield of the product and the production safety and reduce the hygroscopicity of the raw materials. Therefore, the method is more favorable for the industrial mass production. |
priorityDate | 2012-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.