http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103012190-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1bc47340c68d0fbe4baf7863f5330ee2 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-06 |
| filingDate | 2012-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52b810f3542c7d0e163417257e2dd742 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df309ef787a3c2c0f8e4e45bbfe36b45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f867cecc66adef91d9821bea9704121a |
| publicationDate | 2015-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103012190-B |
| titleOfInvention | Synthesis method of S-2-aminobutanamide hydrochloride |
| abstract | The invention discloses a synthesis method of S-2-aminobutanamide hydrochloride, which comprises the following steps of: 1) ammoniation: respectively carrying out ammoniation on methyl 2-bromobutyrate in a methanol-ammonia solution and anhydrous isopropyl alcohol so as to generate DL-2-aminobutanamide; 2) resolving: combining the DL-2-aminobutanamide with an L-tartaric acid to carry out salting-out, and carrying out resolution and purification on the obtained product; and 3) releasing and salifying: directly feeding hydrogen chloride into a crude product subjected to resolution and purification so as to carry out releasing and salifying, thereby obtaining S-2-aminobutanamide hydrochloride with optical activity. The method disclosed by the invention is cheap and easily obtained in raw materials, simple in operation, mild in conditions, high in process safety, low in equipment requirement, and easy to realize industrialized large-scale production. |
| priorityDate | 2012-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.