| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7aecd37740bde551041fdfe76a17ba38 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-65
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-11 |
| filingDate |
2012-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2014-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d12c4c01a8c30669aed5d489ddc8b617
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7546e18dbb5808eb12cc440601938fef
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_11dc5247195dad8a11e20694fa08daf6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a31b72509d99c0cccbf4d12e3ea281ca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54581287e2e2986120553e8c9d08dc93
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f305179b86c104e4cf3b194e1b19728
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4bde7efa3f9ab4b7f9daa30f48e3c60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5658d3d8d654c5eeb3886a4b688bc733
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43877f052e334ad38ca55db3a46f36f6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_153aa9a1961ba3489532cda2660b3f45 |
| publicationDate |
2014-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-103012144-B |
| titleOfInvention |
Preparation method of flurbiprofen axetil |
| abstract |
The invention relates to a preparation method of flurbiprofen axetil. The method comprises the following steps of: preparing 4-bromine-2-fluoroanili from fluoroaniline under the action of 1,3- dibromo-5,5-dimethyl hydantoin; condensing 4-bromine-2-fluoroanili with benzene under the action of a catalyst and sodium nitrite to synthesize 4-bromine-2-fluorobiphenyl; carrying out grignard reaction and acidity reaction on the 4-bromine-2-fluorobiphenyl and 2-bromine sodium propionate under the action of a catalyst to generate 2-(2- fluorine-4-biphenylyl) propionic acid; condensing the 2-(2- fluorine-4-biphenylyl) propionic acid with 1-chloroacetic ethyl acetate to generate a target compound flurbiprofen axetil; and carrying out molecular distillation on the flurbiprofen axetil crude product to obtain a flurbiprofen axetil final product. |
| priorityDate |
2012-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |