http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103012126-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_845b0af94ff83ef2d9449a980c3cd1c8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_641a820a6d43ebb43841f505cae934ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f9ff27001608a152d4ca5b1ab5789e6d |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-347 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C65-24 |
| filingDate | 2012-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_342bed1891ea94889bb34233c3b6052e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_185e405fb4c955335681ff0642e933e4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_700ce08159f6d078e78e5cee0edd4b7c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_110dee5cb8d0d7505a7d0b68b0ee25e9 |
| publicationDate | 2014-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103012126-B |
| titleOfInvention | Preparation method of benzoic acid derivative |
| abstract | The invention discloses a preparation method of a benzoic acid derivative III, which comprises the following steps: by using dimethyl sulfoxide as a solvent, reacting m-hydroxybenzoic acid and 3,4-dichlorobenzotrifluoride at 80-130 DEG C under the action of alkali metal hydroxide by using halogenated cuprous salt and ligand as catalysts, wherein the mol ratio of alkali metal hydroxide to m-hydroxybenzoic acid is 2.0-5.0, and the total mass of halogenated cuprous salt and ligand is 0.5-5% of the mass of the m-hydroxybenzoic acid. The preparation method disclosed by the invention has the advantage of mild reaction conditions, enhances the reaction yield and conversion rate, lowers the isomer generation proportion, and is more suitable for industrial production. |
| priorityDate | 2012-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.