http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103007293-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6cb4ab729c5c94a203059e5d3f32dbeb |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-66 |
| filingDate | 2012-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5cbda8401a62a2f40084b7e213a877bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3325a6ade0f2bd0782c2b1bfc7821e58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4a2e7845dcbe6480b5377fe104e3e8e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad7afb56aa3474118da564239ae7987f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_90f81263c1408f77be29bd7850d3d852 |
| publicationDate | 2014-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103007293-B |
| titleOfInvention | Targeting polypeptide-gene composite as well as preparation method and application of composite |
| abstract | The invention discloses a targeting polypeptide-gene composite. The composite is formed by a binding fusion protein of HIV-Tat (49-57) peptide (RKKRRQRRR) (Human Immunodeficiency Virus Trans-activator of Transcription) and V9 peptide (LTQQMKFVV) and an HIF-1alphashRNA (Hypoxia Inducible Factor-1alpha Short Hairpin Ribonucleic Acid) carrier by means of electrostatic interaction; the composite can use the guide effect of the V9 (CX3C-chemokine receptor 1) receptor on the surface of microglia, and, at the same time when the V9 peptide and the CX3CR1 receptor act with each other, the HIF-1alphashRNA is efficiently transfected into the microglia to interfere with the HIF-1alpha (Hypoxia Inducible Factor-1alpha) expression and inhibit the microglia activation so as to further inhibit the occurrence and progression of a microglia-mediated central nervous system disease. The composite can be applied to the preparation of a medicine for treating the microglia-mediated central nervous system disease and has good development and application prospect in the field of treating the nervous system disease. |
| priorityDate | 2012-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.