http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103006670-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-585 |
| filingDate | 2012-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103006670-B |
| titleOfInvention | Total unsaturated toad lactone, and preparation method and use thereof |
| abstract | The invention discloses a total unsaturated toad lactone, and a preparation method and a use thereof. The preparation method for the total unsaturated toad lactone comprises the following steps: (1), crushing the toad, ultrasonically extracting the crushed toad 3-4 times using ethanol solution, and filtering to remove the dredges to obtain the toad extracting solution; (2), concentrating the toad extracting solution under reduced pressure to obtain pulp as the toad total extract; (3), suspending the toad total extract with water, extracting the suspended toad total extract using dichloromethane, and evaporating under reduced pressure to remove dichloromethane to obtain the dichloromethane part; and (4), dissolving the dichloromethane part with a solvent A and regulating the pH value of the solution to 1-6, stirring and reacting the solution for 1-8 hours at a temperature of 0 DEG C to 100 DEG C, adding water to stop the reaction when at least two compounds of Bu-1, Bu-2, Bu-3, Bu-4 and Bu-5 in the solution are detected, extracting using a solvent B, and evaporating under reduced pressure to remove the solvent B to obtain the total unsaturated toad lactone. The total unsaturated toad lactone disclosed by the invention has the activity of inhibiting male sex hormone dependent form prostate cancer cell multiplication and non-male sex hormone dependent form prostate cancer cell multiplication, and can be used for preparing the medicine for preventing and treating the prostate cancer. |
| priorityDate | 2012-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.