| abstract |
A compound exhibiting ADAM17 inhibitory effect represented by the following general formula (I), or a salt thereof, or a solvate thereof [wherein, X is a phenylene group; Y is a hydrogen atom, or -(CH 2 ) m R 1 etc.; R 1 is -NR 5 COR 2 , -NR 5 SO 2 R 2 or -NR 3 R 4 ; R 2 is C1~C6 alkyl, aryl, or C1~C6 alkoxy; R 3 and R 4 is a C1-C6 alkyl group, etc.; R 5 is a hydrogen atom or a C1-C6 alkyl group, etc.; m is any integer from 0 to 4; Z represents a hydrogen atom or a C1-C6 alkyl group. ] . |