http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102993168-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-465 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2012-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102993168-B |
| titleOfInvention | Streptonigrin analog and preparation method thereof, purposes |
| abstract | The invention discloses a kind of streptonigrin analog and preparation method thereof, purposes.The structural formula of this streptonigrin analog is:n wherein, Rn 1 =OCHn 3 or H, Rn 2 =OCHn 3 , Rn 3 =OCHn 3 ; Or Rn 1 =OCHn 3 , Rn 2 =OH, Rn 3 =OH.The present invention is using streptonigrin producing strains streptomyces flocculus Streptomycesflocculus CGMCC4.1223 as starting strain, respectively selectivity inactivation is carried out to the carboxylesterase gene stnA of this bacterial strain streptonigrin biological synthesis gene cluster and methyl transferase gene stnQ3, obtain Procaine esterase Inactivating mutations bacterial strain Δ stnA and methyltransgerase Inactivating mutations bacterial strain Δ stnQ3; Respectively to this two mutant strain tunning crude extracts separation and purification, to obtain final product.Compound of the present invention can be used for developing anti-tumor medicaments as the analogue of antitumor drug streptonigrin. |
| priorityDate | 2012-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.