http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102993106-B
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e6dab0b3344ab01e596a21deac1ce195 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-24 |
filingDate | 2012-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2015-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25b8ee299aff519661a439003c6e61d9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc3ad43e87c77503bd60dff5f99c4c7c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f5121a0f6a2f56120ff99e84ae6132c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1063729a5c89848cffec56e76ff56e9d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c26f3e3731c0926d2f74ad7cf375f17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d077afbc152350698929f9fd3c48bf86 |
publicationDate | 2015-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-102993106-B |
titleOfInvention | Novel synthesis route of glipizide |
abstract | The invention relates to a novel synthesis route of glipizide, which is characterized by comprising the following steps of protecting 4-(2-amino ethyl)benzenesulfonic acid ammonia (II) by Boc anhydride to obtain a compound (III); reacting the compound (III) with cyclohexyl isocyanate to obtain a compound (IV); carrying out deprotection on the compound (IV) to obtain a compound (V); and reacting the compound (V) with 2-methyl-5-pyrazine carboxylic acid to obtain the glipizide (I) with the single impurity which is less than or equal to 0.5% and the high purity which is more than or equal to 99%. The process is simple, the yield is high, the purity is high and the single impurity is low; and the process is environment-friendly and industrial production is easy to realize. |
priorityDate | 2012-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 57.