http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102989015-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eda37409f26cb8e833ba67f2b1bc1fd5 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-04 |
| filingDate | 2012-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b238bda26a01b01940b951928fc9b2e1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4cd25970505f9622448917931219af7c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38a5706796e327f3b03180cfe5f40214 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4abf59efad827528bd116d70fd6782f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8e89ee439ad3668581c47043113b369 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f61c31f14d01e55498980a19ca23c8c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_731409adf9b2ceeda742f2951251d213 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc6c744b50d27930a71556355b6a49c8 |
| publicationDate | 2014-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102989015-B |
| titleOfInvention | Preparation method of CT imaging molecular probe of folate receptor targeted tumor |
| abstract | The invention discloses a preparation method of a CT imaging molecular probe of folate receptor targeted tumors, which comprises the following steps: dissolving folic acid which is used as a wrapping agent in a solution which contains gold ions and is used for preparing nanogold, adjusting the pH to 7.0-7.5 to obtain a mixed solution, wherein the molar ratio of folic acid to gold ions is 1:2-6; adding a reducing agent into the mixed solution, rapidly stirring and reacting for at least 1 hour, naturally cooling after the reaction, performing dialysis to remove unreacted parts so as to obtain the nanogold coated by folic acid. The nanogold coated by folic acid FA-GNP prepared in the invention has high attenuation capability for X ray, and can be used as a CT imaging contrast agent; the FA-GNP can provide CT images with high contrast for tumors. |
| priorityDate | 2012-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.